Comparison tool
ACE-031 vs Kisspeptin side-by-side
Stack up to four peptides by evidence status, mechanisms, study dosing, side effects, and references.
Comparison tool
Stack up to four peptides by evidence status, mechanisms, study dosing, side effects, and references.
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| Property | ACE-031 | Kisspeptin |
|---|---|---|
| Category | Hormonal | Hormonal |
| Also known as | ACVR2B-Fc, Myostatin Inhibitor | Kisspeptin-10, Kisspeptin-54, Metastin |
| FDA approved | No | No |
| Clinical status | Development halted due to safety concerns
| Investigational - Clinical trials ongoing Not applicable |
| What to expect | Muscle growth research, muscular dystrophy | Fertility, testosterone, reproductive hormone optimization |
| How it works | ACE-031 is an ACVR2B-Fc fusion protein designed to function as a circulating ligand trap. The source describes it as binding myostatin and related TGF-beta superfamily ligands before they can signal through activin type IIB receptors on muscle. This pathway was investigated as a way to reduce growth-inhibitory signaling. Reported bleeding and telangiectasia findings are consistent with concern that activin-receptor signaling also affects vascular biology. | Kisspeptin is described as acting through KISS1R/GPR54 receptors on GnRH neurons in the hypothalamus. The reported intracellular pathway includes phospholipase C activation with IP3 and DAG second messengers, followed by increased GnRH release. GnRH then drives pituitary gonadotropin output, including LH and FSH, linking kisspeptin signaling to ovarian and testicular hormone regulation. The source also notes genetic evidence: inactivating KISS1 or KISS1R mutations are associated with pubertal failure and infertility, while activating mutations are associated with precocious puberty. |
| Typical dosing | Limited community data available · See research protocols | 100-200 mcg subcutaneously once daily · Once daily or every other day |
| Research dosing | 0.5-3 mg/kg every 2 weeks in trials · Every 2 weeks in trials · Trials discontinued · Subcutaneous injection | Kisspeptin-10: 1-10 nmol/kg IV · Variable by protocol · IV (research), subcutaneous (investigational) |
| Typical duration | Trials discontinued | Variable by protocol |
| Administration | Subcutaneous injection | IV (research), subcutaneous (investigational) |
| Timing | Morning, same day each week With or without food | Morning or as directed With or without food |
| Evidence level | Clinical Trials | Clinical Trials |
| Possible side effects |
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| Research summary | The source describes ACE-031 as having been evaluated in humans, including single-ascending-dose work in healthy volunteers and an ascending-dose, placebo-controlled Phase 2 study in ambulatory boys with Duchenne muscular dystrophy. Reported study signals included changes related to lean mass, fat mass, bone measures and 6-minute walk distance. The Duchenne study stopped early after safety findings such as nosebleeds and telangiectasias, and the broader program was discontinued despite no serious or severe adverse events being formally attributed in the source summary. | The supplied evidence reports several human research contexts. In women with hypothalamic amenorrhea, subcutaneous kisspeptin-54 was reported to raise LH about 10-fold and FSH about 2.5-fold into the normal range, and infusion protocols were reported to restore LH pulse frequency. In an IVF setting, kisspeptin-54 was used to trigger oocyte maturation, with a live term birth reported, and the source says it has been explored as a potentially gentler trigger with possible ovarian hyperstimulation risk reduction. In hypogonadal men, kisspeptin-10 infusion reportedly increased LH roughly 5-fold and moved testosterone into the normal range. The same source cautions that these data mainly come from small academic studies and specialist infusion protocols, not large multi-center phase 3 trials, and that short-term hormone changes do not establish long-term safety. |
| References | ||
| Full profile | View Details | View Details |
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Track your peptide journeyEducational use only. This information is aggregated from public research and community reports. It is not medical advice, and dosing details are descriptive, not recommendations. Always consult a qualified healthcare professional.