Comparison tool
Thymalin vs Epithalon side-by-side
Stack up to four peptides by evidence status, mechanisms, study dosing, side effects, and references.
Comparison tool
Stack up to four peptides by evidence status, mechanisms, study dosing, side effects, and references.
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| Property | Thymalin | Epithalon |
|---|---|---|
| Category | Bioregulators | Bioregulators |
| Also known as | Thymic Factor, Thymus Extract | Epitalon, Epithalone, AGAG |
| FDA approved | No | No |
| Clinical status | Approved in Russia - Not FDA approved Not applicable | Investigational; primarily Russian research. Source notes current FDA Category 2 status pending formal reclassification activity in 2026.
|
| What to expect | Immune support, thymic function, longevity | Longevity, telomere support, anti-aging, sleep |
| How it works | Thymalin is presented as a thymus-derived peptide mixture with short identified fractions such as EW and KE. The proposed mechanism is immunomodulatory and gene-regulatory: source material links these peptides to interactions with DNA or histone-associated regions that may influence cytokine signaling, heat-shock protein expression, cellular differentiation, T- and B-lymphocyte function, and phagocytosis. Because the material is a complex extract, the evidence does not support reducing its action to one receptor or one molecular target. | Epithalon is proposed to act through telomerase-related biology, with cell-culture reports describing telomerase activity and telomere elongation in human fibroblasts. The source also notes possible effects on melatonin, antioxidant defenses, and gene expression in pineal-hypothalamic pathways. Translation from these observations to meaningful human anti-aging outcomes remains unproven in the supplied evidence. |
| Typical dosing | 10-20 mg daily for 5-10 days · Daily during cycles | 5-10 mg daily for 10-20 days · Once daily in cycles · 10-20 days |
| Research dosing | 10 mg daily for 10 days · 10-day cycles, 1-2 times yearly · Intramuscular injection | 5-10 mg daily for 10-20 days · 10-20 day cycles · Subcutaneous or intramuscular injection |
| Typical duration | 10-day cycles, 1-2 times yearly | 10-20 day cycles |
| Administration | Intramuscular injection | Subcutaneous or intramuscular injection |
| Timing | Morning With or without food | Before bed With or without food |
| Evidence level | Clinical Trials | Clinical Trials |
| Possible side effects |
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| Research summary | The supplied research summary places most Thymalin literature in Russian and Khavinson-associated research programs, spanning cell experiments, animal studies, observational work, and clinical reports. It cites reviews describing lymphocyte and immune-function findings, fewer acute respiratory disease observations in older groups, geroprotective claims, mortality observations in older subjects receiving thymus and pineal peptides, and a study of immune-status regulation in severe COVID-19 among older patients. The source also cautions that although some randomized or placebo-controlled data exist, studies are commonly small, regionally concentrated, and not replicated at a scale expected for major Western regulatory review. | The supplied research narrative gives greatest weight to laboratory and animal data. It cites a 2003 report by Khavinson and colleagues on telomerase activity and telomere changes in cultured human fibroblasts, plus a 2025 review discussing geroprotective and neuroendocrine research. Animal studies are described as reporting lifespan and tumor-incidence findings. Human evidence is characterized as limited, often small or open-label, and not independently replicated at the scale needed to prove lifespan extension or reliable telomere-length effects in people. |
| References | ||
| Full profile | View Details | View Details |
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Track your peptide journeyEducational use only. This information is aggregated from public research and community reports. It is not medical advice, and dosing details are descriptive, not recommendations. Always consult a qualified healthcare professional.