Thymogen is the brand name for L-Glu-L-Trp, also called glutamyl-tryptophan or EW. The source describes this dipeptide as the smallest active portion associated with the calf-thymus extract Thymalin. It reports Russian clinical use since 1990, while noting no Western approval or evaluation and limited rigorous independent trials.

Is Thymogen FDA approved?

No. The source lists Thymogen as not FDA approved. It separately reports clinical immunomodulation use in Russia.

What adverse effects does the source report?

The source reports general tolerability and no significant side effects reported during clinical use. It also lists rare allergic reactions and individual intolerance to components as possible effects, and says experiences can vary with amount, duration, and personal health factors.

What dosing has the source reported?

The source labels 1-2 capsules, totaling 10-20 mg daily, as a community-reported amount, with use described as 1-2 times daily before meals. It also reports oral capsules and nasal spray in some regions, states that this is not FDA-approved dosing, and directs readers to a healthcare provider.

Immune Clinical Trials - human trials under way

Thymogen

Also known as: EW Dipeptide, Glu-Trp, L-Glutamyl-L-Tryptophan, Oglufanide

At a glance

PeptiGuide dataset · reviewed Aug 2026

What it is

L-Glu-L-Trp dipeptide with source-reported immune research and limited independent clinical evidence.

Status

Clinical Trials

Evidence level: human studies

Typical dose

10–20mg

Oral capsules

Researched for

Immune modulation, T-cell support, immune aging

Trial progress

PrePreclinical
IPhase I
IIPhase II
IIIPhase III
IVPhase IV
FDAFDA approved

Phase II - Emerging human evidence with important limitations

Use the tools

In plain language

Identity: Thymogen is L-Glu-L-Trp (EW), a dipeptide described as a small active fraction associated with the calf-thymus extract Thymalin.
Evidence: the source reports Russian clinical immunomodulation use since 1990 and labels the evidence Human Trials, but also notes a lack of rigorous independent trials and no Western approval or evaluation.
Forms and reported use: oral capsules are described, with nasal spray available in some regions; the listed amounts are community-reported rather than approved dosing.

How it's thought to work

The source describes an immunomodulatory hypothesis rather than a fully defined target. Reported experimental findings associate L-Glu-L-Trp with T-cell differentiation, -MHC recognition, altered intracellular cyclic nucleotides, and increased neutrophil chemotaxis and phagocytosis. It also notes reported DNA-level gene-expression effects. The initiating molecular mechanism remains unresolved, and the source presents immune effects as more documented than the gene-expression claims.

What the research shows

Where the research stands

The source describes a 2000 Anisimov Biogerontology experiment in which the dipeptide was given to rats. It reports associations with greater maximum lifespan, lower tumor incidence, and an approximately 3.4-fold reduction in blood cancers versus controls; this was not a human trial. It characterizes the broader clinical and laboratory literature as predominantly older Russian-language work linked to the original developers, with limited independent Western replication. According to the source, contemporary external randomized controlled trials have not confirmed immune or anti-aging claims to current evidence standards.

What it shows

✓ Human studies

Emerging human evidence with important limitations

△ Limitations

Study protocols describe research and are not dosing recommendations.

Bottom line: Source-reported: approved in Russia for clinical immunomodulation; used since 1990. Not FDA Approved

Typical dosing

CommunityCommunity dataset

10–20 mg

) daily

10 mg/dayfull range seen20 mg/day

The source describes it as a Khavinson bioregulator, reports decades of Russian clinical use and 30-day cycles with breaks, and mentions Vilon and Thymalin as other thymus peptides.

Research dosing

Study-specific protocolsHuman trials under way - protocols are study-specific

Doses observed in studies

10-20 mg daily oral

Russian Clinical Practice - Over 20 years of clinical immunomodulation use

Study protocols describe research and are not dosing recommendations.

Duration: 30-day courses with 2-3 month breaks
Administration: Oral capsules, also available as nasal spray in some regions

Timing & administration

Best time to take

Morning, before meals

1-2 times daily

Food recommendation

With or without food

Why this timing?

The source associates morning timing with daytime immune activity, but supplies no comparative timing study.

Possible side effects

Not everyone experiences these. Individual responses vary with dose, duration, and personal factors.

Generally well-tolerated
No significant side effects reported in clinical use
Rare allergic reactions possible
Individual intolerance to components

Not everyone experiences side effects, and severity can vary by context, purity, route, and individual health factors.

Sources

PubMed ClinicalTrials.gov FDA.gov

Frequently asked questions

The source presents an immunomodulatory hypothesis rather than a defined molecular target. Its reported experiments associate the dipeptide with T-cell differentiation, peptide-MHC recognition, changes in intracellular cyclic nucleotides, and increased neutrophil chemotaxis and phagocytosis. It also notes DNA-level gene-expression reports, but says the initiating trigger remains unclear and that immune effects are better documented.

Sequence

Glu-Trp

One open dataset

Every fact on this page - doses, side effects, references - comes from the same PeptiGuide dataset that powers the Tracker, Compare, and the Lab.

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Educational resource, not medical advice. Talk to your clinician before acting on anything here.

Community discussion

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Thymogen

In plain languageIn plain language

How it's thought to workHow it's thought to work

What the research showsWhat the research shows

Typical dosing

Research dosing

Timing & administrationTiming & administration

Possible side effectsPossible side effects

SourcesSources

Frequently asked questionsFrequently asked questions

What is Thymogen?

What mechanism has been reported for Thymogen?